vancomycin resistant enterococcus faecalis  (ATCC)

Journal: MicrobiologyOpen

Article Title: Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus , Enterococcus faecalis , and Their Biofilms

doi: 10.1002/mbo3.70011

Figure Lengend Snippet: Minimum inhibitory concentrations (MICs, mg/L) against drug‐resistant S. aureus and E. faecalis strains.

Article Snippet: Compound 22 f displayed activities against Neisseria gonorrhoeae (ATCC 49226; MIC of 1 mg/l), one flucloxacillin‐resistant S. aureus strain ( S. aureus NCTC 12493; MIC = 1 mg/L) and two vancomycin‐resistant Enterococcus faecalis (VRE) strains (NCTC 12201 ‐ MIC = 0.250 mg/L and ATCC 51299 ‐ MIC = 2 mg/L).

Techniques:

Journal: MicrobiologyOpen

Article Title: Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus , Enterococcus faecalis , and Their Biofilms

doi: 10.1002/mbo3.70011

Figure Lengend Snippet: Minimum Inhibitory Concentrations (MICs, mg/l) of two selected compounds and four comparative agents against a panel of S. aureus (Panel A), E. faecalis (Panel B) and E. faecium (Panel C). Panel A ‐ All clinical strains of S. aureus (blue line), except for the final three standard S. aureus strains (ATCC 29213, ATCC 700698 and ATCC 700699, black line). MSSA = methicillin‐sensitive Staphylococcus aureus ; S = sensitive; GISA = glycopeptide‐intermediate S. aureus ; hGISA = hetero‐GISA; Panel B ‐ All clinical strains of E. faecalis (blue line), except for the final three ATCC/NTC strains (black line). VRE = vancomycin‐resistant enterococci; S = sensitive short for MSSA ‐ methicillin‐sensitive S. aureus ; Panel C ‐ VRE = vancomycin‐resistant enterococci; S = sensitive. Comparative agents: Van – Vancomycin; Lzd – Linezolid; Teic ‐ Teicoplanin; Dap – Daptomycin. A colour code was used based on the highest (in blue) to the lowest MIC value (in green) of the data set (the coloured bar, mg/l, is included on the left‐hand side of the picture). The highest range of the colour mapping was set to 2.00 (Panel A) or 4.00 (Panels B and C) for visualisation purposes.

Article Snippet: Compound 22 f displayed activities against Neisseria gonorrhoeae (ATCC 49226; MIC of 1 mg/l), one flucloxacillin‐resistant S. aureus strain ( S. aureus NCTC 12493; MIC = 1 mg/L) and two vancomycin‐resistant Enterococcus faecalis (VRE) strains (NCTC 12201 ‐ MIC = 0.250 mg/L and ATCC 51299 ‐ MIC = 2 mg/L).

Techniques: Glycoproteomics

Journal: MicrobiologyOpen

Article Title: Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus , Enterococcus faecalis , and Their Biofilms

doi: 10.1002/mbo3.70011

Figure Lengend Snippet: Pre‐exposure of S. aureus and E. faecalis to quinoxaline analogues decreases their sensitivities.

Article Snippet: Compound 22 f displayed activities against Neisseria gonorrhoeae (ATCC 49226; MIC of 1 mg/l), one flucloxacillin‐resistant S. aureus strain ( S. aureus NCTC 12493; MIC = 1 mg/L) and two vancomycin‐resistant Enterococcus faecalis (VRE) strains (NCTC 12201 ‐ MIC = 0.250 mg/L and ATCC 51299 ‐ MIC = 2 mg/L).

Techniques: Analogues

Journal: MicrobiologyOpen

Article Title: Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus , Enterococcus faecalis , and Their Biofilms

doi: 10.1002/mbo3.70011

Figure Lengend Snippet: Pre‐exposure of S. aureus and E. faecalis to compounds 25 and 31 and impact on cross resistance to clinically available antibiotics.

Article Snippet: Compound 22 f displayed activities against Neisseria gonorrhoeae (ATCC 49226; MIC of 1 mg/l), one flucloxacillin‐resistant S. aureus strain ( S. aureus NCTC 12493; MIC = 1 mg/L) and two vancomycin‐resistant Enterococcus faecalis (VRE) strains (NCTC 12201 ‐ MIC = 0.250 mg/L and ATCC 51299 ‐ MIC = 2 mg/L).

Techniques:

Journal: MicrobiologyOpen

Article Title: Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus , Enterococcus faecalis , and Their Biofilms

doi: 10.1002/mbo3.70011

Figure Lengend Snippet: MBC values of compounds 25 and 31 against S. aureus and E. faecalis .

Article Snippet: Compound 22 f displayed activities against Neisseria gonorrhoeae (ATCC 49226; MIC of 1 mg/l), one flucloxacillin‐resistant S. aureus strain ( S. aureus NCTC 12493; MIC = 1 mg/L) and two vancomycin‐resistant Enterococcus faecalis (VRE) strains (NCTC 12201 ‐ MIC = 0.250 mg/L and ATCC 51299 ‐ MIC = 2 mg/L).

Techniques:

Journal: MicrobiologyOpen

Article Title: Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus , Enterococcus faecalis , and Their Biofilms

doi: 10.1002/mbo3.70011

Figure Lengend Snippet: Quinoxaline analogues induce phenotypic alterations to the surface of both S. aureus and E. faecalis . Scanning electron micrographs of S. aureus ATCC 29213 (A–F) and E. faecalis NCTC 12201 (G–L). Panels A and G and Panels B and H represent untreated cells captured at 20,000‐ and 50,000‐times magnification, respectively. Bacteria treated with 2x MBC concentration of compound 25 are depicted in Panels C and I as well as Panels D and J at 20,000‐ and 50,000‐times magnification, respectively. Bacteria treated with 2 x MBC concentration of compound 31 are shown in Panels E and K as well as Panels F and L at 20,000‐ and 50,000‐times magnification, respectively. Blue arrows: loss of cellular content; red arrows: wrinkled cell surfaces; black arrow: cells that appear to have collapsed.

Article Snippet: Compound 22 f displayed activities against Neisseria gonorrhoeae (ATCC 49226; MIC of 1 mg/l), one flucloxacillin‐resistant S. aureus strain ( S. aureus NCTC 12493; MIC = 1 mg/L) and two vancomycin‐resistant Enterococcus faecalis (VRE) strains (NCTC 12201 ‐ MIC = 0.250 mg/L and ATCC 51299 ‐ MIC = 2 mg/L).

Techniques: Analogues, Bacteria, Concentration Assay

Journal: MicrobiologyOpen

Article Title: Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus , Enterococcus faecalis , and Their Biofilms

doi: 10.1002/mbo3.70011

Figure Lengend Snippet: Quinoxaline analogues showed better anti‐biofilm activities (MBEC) compared to five selected comparative antibiotics.

Article Snippet: Compound 22 f displayed activities against Neisseria gonorrhoeae (ATCC 49226; MIC of 1 mg/l), one flucloxacillin‐resistant S. aureus strain ( S. aureus NCTC 12493; MIC = 1 mg/L) and two vancomycin‐resistant Enterococcus faecalis (VRE) strains (NCTC 12201 ‐ MIC = 0.250 mg/L and ATCC 51299 ‐ MIC = 2 mg/L).

Techniques: Analogues

Journal: Advanced Science

Article Title: Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics

doi: 10.1002/advs.202411406

Figure Lengend Snippet: MICs of the individual components of CTZ‐R6 and the conjugate against different Gram‐positive and CTZ‐sensitive Gram‐negative strains. Data is shown as median ( n = 3).

Article Snippet: Synergies between ceftazidime and CTZ‐R6, ceftazidime and vancomycin (VAN), and CTZ‐R6 and VAN were investigated on the vancomycin‐resistant enterococci E. faecalis ATCC 51 299 and E. faecium UL 602 570.

Techniques:

Journal: Journal of Fungi

Article Title: Diversity and Anti-Infectious Components of Cultivable Rhizosphere Fungi Derived from Three Species of Astragalus Plants in Northwestern Yunnan, China

doi: 10.3390/jof10110736

Figure Lengend Snippet: Antibacterial screening of rhizosphere fungi associated with Astragalus acaulis (Aa), A. forrestii (Af) and A. ernestii (Ae) against seven strains of Gram-positive pathogenic bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300, S. aureus ATCC 25923, S. epidermidis ATCC 12228, vancomycin-resistant Enterococcus faecalis (VREF) ATCC 51299, E. faecalis ATCC 29212, E. faecium ATCC 35667 and Streptococcus agalactiae ATCC 13813 (µg/mL).

Article Snippet: Specifically, the extract of strain AA12 revealed the strongest antibacterial against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300, S. aureus ATCC 25923 and Enterococcus faecalis ATCC 29212 with the MIC values of 6.25 μg/mL and showed significant inhibition for S. epidermidis ATCC 12228, vancomycin-resistant Enterococcus faecalis (VREF) ATCC 51299 and E. faecium ATCC 35667 with the MIC values of 12.5 μg/mL and Streptococcus agalactiae ATCC 13813 with the MIC value of 25 μg/mL.

Techniques: Bacteria, Positive Control

Journal: Journal of Fungi

Article Title: Diversity and Anti-Infectious Components of Cultivable Rhizosphere Fungi Derived from Three Species of Astragalus Plants in Northwestern Yunnan, China

doi: 10.3390/jof10110736

Figure Lengend Snippet: Antibacterial activity of the compounds 1 – 7 against seven strains of Gram-positive pathogenic bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300, S. aureus ATCC 25923, S. epidermidis ATCC 12228, Vancomycin-resistant Enterococcus faecalis (VREF) ATCC 51299, E. faecalis ATCC 29212, E. faecium ATCC 35667 and Streptococcus agalactiae ATCC 13813 (µg/mL).

Article Snippet: Specifically, the extract of strain AA12 revealed the strongest antibacterial against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300, S. aureus ATCC 25923 and Enterococcus faecalis ATCC 29212 with the MIC values of 6.25 μg/mL and showed significant inhibition for S. epidermidis ATCC 12228, vancomycin-resistant Enterococcus faecalis (VREF) ATCC 51299 and E. faecium ATCC 35667 with the MIC values of 12.5 μg/mL and Streptococcus agalactiae ATCC 13813 with the MIC value of 25 μg/mL.

Techniques: Activity Assay, Bacteria